Chloramphenicol 20% W.S.P

Composition:

 Each 100 gm contain 20 gm chloramphenicol.

Action: 

- Chloramphenicol is abroad spectrum antibiotic active against Gm+ve, Gm-ve bacteria, spirochaetes and rickettsiae.

- After administration within 2 hrs. blood levels of it is increased, which are mintained for at least 24 hrs. 

Indications:

  Gastroenteritis, pneumoina, polyarthritis, metritis, infections of urinary tract and infectious diarrhea.

Contraindications:

1- Hypersensitivity to chloramphenicol, in newborns, liver dysfunction.

2- Not administered during gestation and lactation period.

3- Not used in cases of mastitis. 

Sid effects:

 Long term treatment may cause reversible depression of hematopieosis, intestinal disturbances and seldom an irreversable bone marrow toxicity resulting in fatal aplastic anemia.

Drug interactions: 

1- Chloramphenicol can inhibit the hepatic metabolism of several drugs including phenobarbital and pentobarbital.

2- Possible antagonism with bactericide antibiotic such as Penicillin, Amino glycosides and Cephalosporines.

3- Rifampin may decrease serum Chloramphenicol level.

Dosage:

 40 - 80 mg./kgm. body weight.

Withdrawal Time: 

1- Meat 3 weeks.

2- Milk  3 days.

Packing: 200 gm, 500 gm 

Storage:

 Cool dry place away from direct sunlight.

note:

1- Stability 2-3 years.

2- Medicated water should be supplied within 24 hrs.